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Contrave is a combination of the drugs naltrexone and bupropion, which usually reflect a brand new trend of weight-loss drugs that are made up of several active ingredient, which can make them more potent and safer. Combo-pilling may be the newest fad or also the newest ahead under scrutiny and therefore it is just more publicly known although in the past, comb-pilling for weight reduction has been around since the eighties. The biggest reason that utilizing a combination of pills has become popular is the fact that at the time of right now there aren't any long term prescription diet pills that have been approved by the FDA aside from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations are actually rejected or have yet to be licensed by the FDA. Seizures certainly are a side effect with Contrave and mustn't be taken in individuals with seizure disorders. The drug can also raise blood pressure levels and heart rate, and shouldn't be used in those with a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise blood pressure level and pulse rate and must stop used in patients with uncontrolled high hypertension, and also by a person with heart-related and cerebrovascular (circulation dysfunction impacting your brain) disease. Patients with a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes having a boxed warning to alert medical researchers and patients on the increased risk of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stop smoking. From a psychiatric standpoint, evidence implies that the ordinary neural mechanism for goal-directed behavior has been hijacked from the addiction, and malfunctions in a way that its ordinary functions are exaggerated and fixated on its object. An object creates a stimulus and the person engages in a "goal-directed behavioral response" that creates a "natural high"(Bostwick & Bucci, 2008).

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